ABSTRACT
PURPOSE: Numerous materials, both autologous and nonautologous, have been used for augmentation of sunken areas and each has its own limitations. The ideal material for augmentation should not be absorbed in any manner. This study is designed to assess the survival of SureDerm(R), Permacol(R) graft according to the volume and histologic change. METHODS: Twenty four mice, weighing about 50 grams and of 5 weeks of age were used. SureDerm(R) is an acellular dermal matix obtained from human cadaveric skin. Permacol(R) is a porcine derived acellular dermal matrix whose manufacture involves trypsinisation, solvent extraction. Graft pieces standardized to 1x1cm size were used in each group. The implanted material were taken 1, 4, 8 and 12 weeks later, respectively. The changes of graft volume during the graft period were measured on initial, 1, 4, 8 and 12 weeks. RESULTS: The initial shape of graft was maintained up to 12 weeks in Permacol(R) graft group and mean survival rate was 80.36+/-8.21% in SureDerm(R), 89.57+/-6.39% in Permacol(R)(p=0.01). The volume of each graft decreased 29% from initial volume on 12 weeks in SureDerm(R), 18% in Permacol(R). The structure of Permacol(R) remained until 12 week after implantation. CONCLUSION: Our experimental study suggests that Permacol(R) could be a safe material as an implant for permanent augmentation. However, There are further study remained for antigenicity of these material, and the choice of graft for augmentation should be remained to the clinical situations.
Subject(s)
Animals , Humans , Mice , Acellular Dermis , Cadaver , Graft Survival , Skin , Survival Rate , TransplantsABSTRACT
PURPOSE: This study was to investigate how the heparin, which has been known to induce neovascularization by MMP in the infarcted tissue of the myocardium, had influence on the expression of mRNA of MMP 1,2,9 of the skin wound of rat. METHODS: Full depth skin wounds were created on the dorsum of Sprague-Dawley 60 rats. The experimental rats were divided into two groups according to the concentration of heparin(100microgram/ml in 20, 300microgram/ml in 20). Heparin soaked gelatin sponges in different concentration were inserted into the pocket of experimental rats and the wounds were closed. Normal saline soaked gelatin sponges were used in control rats. Wounds were harvested at 48 and 72 hours after closure. We performed histologic study in H-E stain. RNA was isolated from the harvested tissue and then real time polymerase chain reaction was performed to determine the gene expression of MMP-1,2,9. RESULTS: We observed that inflammatory cell decreased in heparin soaked group and heparin increased the expression of MMP-1,9 mRNA of dorsal wound of rat at 72 hours (p<0.05). CONCLUSION: This result suggest that heparin may be used inducing another factor inducing scarless wound healing by increasing MMP.
Subject(s)
Adult , Animals , Humans , Rats , Gelatin , Gene Expression , Heparin , Myocardium , Porifera , Rats, Sprague-Dawley , Real-Time Polymerase Chain Reaction , RNA , RNA, Messenger , Skin , Wound Healing , Wounds and InjuriesABSTRACT
The aim of this study is to establish anatomical dimension of the lip in young population in Korean, using specially designed soft ware with photographic image. We measure 13 anatomical dimensions of lips in 2,229 young people. (917 male, 1312 female, Aged from 18-33 years. Average age 19.7). Statistical analysis of these measurements of large population could offer useful information in facial plastic surgery. The mean measurements are as follows 1. Lengths (male/female) Widths of philtrum: 1.11+/-0.19cm/1.02+/-0.21cm Heights of philtrum: 1.6+/-0.24cm/1.47+/-0.21cm Heights of cupid bow: 0.88+/-0.16cm/0.83+/-0.16cm Height of upper vermilion: 0.74+/-0.16cm/0.70+/-0.15cm Height of lower vermilion: 1.08+/-0.17cm/1.02+/-0.15cm Height of upper lip(Rt.): 1.24+/-0.2cm/1.23+/-0.2cm Height of upper lip(Lt.): 1.24+/-0.2cm/1.17+/-0.19cm Half horizontal length of lip: 2.2+/-0.26cm/2.11+/-0.2cm Horizontal length of lip: 4.41+/-0.4cm/4.25+/-0.36cm Height of lower face: 7.1+/-0.58cm/6.52+/-0.6cm 2. Angles Nasolabial angle: 97.77+/-11.97degrees/95.5+/-11.34 degrees Mentolabial angle: 133.88+/-14.65 degrees/129.27+/-13.67 degrees Angle of Cupid's bow: 111.65+/-13.99degrees/116.75+/-16.2 degrees Previous reported photogrammetric measurements was difficult to implement to surgical practice. Because these were printed photographies of the same size. Therefore, in this study, we can measure a lot of objects and items more conveniently and correctly by using proportional program on computer after taking a digital photograph. Consequently, proportional measurements with photogrammetry of lip could be useful and corrective substitute for anthropometrical measuring. These data could be useful reference for preoperative consultation, surgical planning and learning anatomical measurement of lips and adjacent structures.
Subject(s)
Adolescent , Female , Humans , Male , Anthropometry , Learning , Lip , Photogrammetry , Photography , Surgery, PlasticABSTRACT
For its lowerlid entropion correction, nonsurgical eyelid suture or surgical eyelid suture can be employed. Different types of surgical eyelid suture such as the Hotz method and the Callahan method, are generally performed, but were not sufficient for correcting of entropion. In our hospital we performed modified skin-tarsal fixation on 15 patients, 5 male and 10 female from January 20, 1999 to December 16, 2002. We corrected lower eyelid entropion with the excision of the skin and orbicularis oculi muscle and buried suture of tarsal plate and dermis which is a variant of the Callahan method. All the patients were satisfied with the operation results, and there was no case of recurrence of the lower eyelid pricking the cornea. During the 6 months period after the operation, the lower eyelids slightly turned inward but there was no further progression. The correction was performed excessively, therefore there was no case of recurrence after the operation and the results were satisfactory. There developed a dimple at the suture margin caused by skin contraction but it usually disappeared within 2 months after the operation. To avoid recurrence and to achieve satisfactory results, the orbicularis oculi muscle must be totally resected at the ciliary margin. We resected ciliary as well as pretarsal portion of orbicularis oculi muscle. Also, since most of the recurrences are originated from the medial side, the medial portion of skin flap must be tightly fixed to avoid recurrence and the upper part of the dermis should be fixed tightly to the lower border of the tarsal plate.
Subject(s)
Female , Humans , Male , Cornea , Dermis , Entropion , Eyelids , Recurrence , Skin , SuturesABSTRACT
No abstract available.
ABSTRACT
Actinomycosis is a chronic suppurative and granulomatous bacterial infection characterized by contiguous spread, abscess formation and sinus tract formation. There are four clinical forms according to the lesional site, as 1) cervicofacial, 2) thoracic, 3) abdominal, and 4) disseminated form. Recently, we experienced a case of 54 year-old patient with left mandibular actinomycosis. The pathognomonic findings of actinomycosis is sulfur granule with multiple filaments in Gram-stain and the treatment of actinomycosis is surgical excision of mass or sinus tract with massive antibiotics (esp. Penicillin) therapy for 6 to 12 months.
Subject(s)
Humans , Abscess , Actinomycosis , Anti-Bacterial Agents , Bacterial Infections , Penicillins , SulfurABSTRACT
Lipomas are common soft tissue that are usually located in the subcutaneous tissue. And intramuscular lipomas commonly arise in the upper and lower extremities, where they usually involve the large muscles. Intramuscular lipoma, also referred to as an infiltrating lipoma, is an unusual benign slow growing tumor composed of mature fat cell interdigitating with skeletal muscle. However, intramuscular lipomas are exceedingly rare in the face. We have been experienced a case intramuscular lipoma that located in the malar area. Because of the rarity of these tumors and their propensity to recur without adequate surgery, the case report is presented here. Achievement of surgical margin is essential as the recurrent rate may be as high as 15% to 62.5% without complete excision.